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IGHD Antibody (N-term) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - IGHD Antibody (N-term) (Ascites) AM2141a
    IGHD Antibody (N-term)(Ascites)(Cat. #AM2141a) western blot analysis in CEM cell line lysates (35μg/lane).This demonstrates the IGHD antibody detected the IGHD protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P01880
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 607CT8.4.4
Calculated MW 42254 Da
Antigen Region 37-64 aa
Additional Information
Other Names Ig delta chain C region, IGHD
Target/Specificity This IGHD antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-64 amino acids from the N-terminal region of human IGHD.
Dilution WB~~1:100~800
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGHD Antibody (N-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGHD
Function IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
Cellular Location Isoform 1: Secreted.
Research Areas
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Background

IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

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$ 295.00
Cat# AM2141a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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