|Application ||WB, E|
|Other Accession||P13904, Q02346, P49811, P10085, P16075, Q7YS82, NP_002469, P29331|
|Predicted||Bovine, Chicken, Mouse, Pig, Rat, Xenopus|
|Calculated MW||34501 Da|
|Antigen Region||105-134 aa|
|Other Names||Myoblast determination protein 1, Class C basic helix-loop-helix protein 1, bHLHc1, Myogenic factor 3, Myf-3, MYOD1, BHLHC1, MYF3, MYOD|
|Target/Specificity||This MyoD1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 105-134 amino acids from the N-terminal region of human MyoD1.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MyoD1 Antibody (N-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHC1, MYF3, MYOD|
|Function||Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.
Xynos, A., et al. Stem Cells 28(5):965-973(2010)
Stuelsatz, P., et al. J. Biol. Chem. 285(17):12670-12683(2010)
Hiraoka, S., et al. Hum. Pathol. 41(1):38-47(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Yang, Z., et al. Genes Dev. 23(6):694-707(2009)
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