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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LOX Antibody (Center)   

LOX Antibody (Center)

Mouse Monoclonal Antibody (Mab)

  • WB - LOX Antibody  (Center) AM2166b
    LOX Antibody (Center) (Cat. #AM2166b) western blot analysis in MDA-MB231 cell line lysates (35μg/lane).This demonstrates the LOX antibody detected the LOX protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28300
Other Accession P16636, P45845, P28301, NP_002308.2
Reactivity Human
Predicted Mouse, Pig, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 624CT23.7.3
Calculated MW 46944 Da
Antigen Region 234-260 aa
Additional Information
Gene ID 4015
Other Names Protein-lysine 6-oxidase, Lysyl oxidase, LOX
Target/Specificity This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLOX Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LOX
Function Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
Cellular Location Secreted, extracellular space.
Tissue Location Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Research Areas
Citations (0)

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The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.


Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18892-18897(2010)
Santhanam, A.N., et al. Oncogene 29(27):3921-3932(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :

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$ 295.00
$ 99.00
Cat# AM2166b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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