|Application ||WB, E|
|Other Accession||P16636, P45845, P28301, NP_002308.2|
|Predicted||Mouse, Pig, Rat|
|Calculated MW||46944 Da|
|Antigen Region||234-260 aa|
|Other Names||Protein-lysine 6-oxidase, Lysyl oxidase, LOX|
|Target/Specificity||This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LOX Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Heart, placenta, skeletal muscle, kidney, lung and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18892-18897(2010)
Santhanam, A.N., et al. Oncogene 29(27):3921-3932(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
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