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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NR3C1 Antibody   

NR3C1 Antibody

Mouse Monoclonal Antibody (Mab)

     
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  • WB - NR3C1 Antibody AM2187b
    NR3C1 Antibody (N-term) (Cat. #AM2187b) western blot analysis in Jurkat,HepG2,mouse NIH/3T3 cell line and mouse liver tissue lysates (35μg/lane).This demonstrates the NR3C1 antibody detected the NR3C1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P04150
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgM,k
Clone Names 740CT12.1.5
Calculated MW 85659 Da
Antigen Region 136-164 aa
Additional Information
Gene ID 2908
Other Names Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL
Target/Specificity This NR3C1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from human NR3C1.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNR3C1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR3C1
Synonyms GRL
Function Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
Cellular Location Cytoplasm. Mitochondrion. Nucleus Note=Cytoplasmic in the absence of ligand, nuclear after ligand- binding
Tissue Location Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
Research Areas
Citations (0)

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Background

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).

References

Hollenberg S.M., et al. Nature 318:635-641(1985).
Encio I.J., et al. J. Biol. Chem. 266:7182-7188(1991).
Wang W., et al. Nucleic Acids Res. 39:44-58(2011).
Turner J.D., et al. Ann. N. Y. Acad. Sci. 1095:334-341(2007).
Munroe D.G., et al. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# AM2187b
Size:
(40 western blots)
Alternative Products:

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