|Application ||WB, E|
|Calculated MW||37607 Da|
|Other Names||Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5, UCHL5, UCH37|
|Target/Specificity||Purified His-tagged UCH37 protein was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UCH37 (UCHL5) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus|
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Provided below are standard protocols that you may find useful for product applications.
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Yao T., et al. Nat. Cell Biol. 8:994-1002(2006).
Lai C.-H., et al. Genome Res. 10:703-713(2000).
Hu R.-M., et al. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Kalnine N., et al. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Gregory S.G., et al. Nature 441:315-321(2006).
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