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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NFKBIA Antibody   

NFKBIA Antibody

Mouse Monoclonal Antibody (Mab)

     
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  • WB - NFKBIA Antibody AM2205b
    NFKBIA Antibody (Cat. #AM2205b) western blot analysis in Hela,mouse NIH/3T3 cell line lysates (35μg/lane).This demonstrates the NFKBIA antibody detected the NFKBIA protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P25963
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,κ
Clone Names 1121CT8.6.1
Calculated MW 35609 Da
Additional Information
Gene ID 4792
Other Names NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3, NFKBIA, IKBA, MAD3, NFKBI
Target/Specificity Purified His-tagged NFKBIA protein was used to produced this monoclonal antibody.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNFKBIA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NFKBIA
Synonyms IKBA, MAD3, NFKBI
Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Research Areas
Citations (0)

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Background

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

References

Huxford T., et al. Cell 95:759-770(1998).
Cockman M.E., et al. Proc. Natl. Acad. Sci. U.S.A. 103:14767-14772(2006).
Haskill S., et al. Cell 65:1281-1289(1991).
Jungnickel B., et al. J. Exp. Med. 191:395-402(2000).
Liu B., et al. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
$ 99.00
Cat# AM2205b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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