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TPIPb Antibody (C-term)(Ascites)

Mouse Monoclonal Antibody (Mab)

     
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  • WB - TPIPb Antibody (C-term)(Ascites) AM2224a
    TPIPb Antibody (C-term)(Cat. #AM2224a) western blot analysis in 293,A431,A2058,mouse NIH/3T3 cell line lysates (35μg/lane).This demonstrates the TPIPb antibody detected the TPIPb protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6XPS3
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 978CT6.1.4
Additional Information
Other Names Phosphatidylinositol 3, 5-trisphosphate 3-phosphatase TPTE2, Lipid phosphatase TPIP, TPTE and PTEN homologous inositol lipid phosphatase, TPTE2, TPIP
Target/Specificity Purified His-tagged TPIPb protein was used to produced this monoclonal antibody.
Dilution WB~~1:5000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTPIPb Antibody (C-term)(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPTE2
Synonyms TPIP
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific EMBL; AJ421032; CAD13144.1; -; mRNA EMBL; AJ421033; CAD13145.1; -; mRNA EMBL; AY219890; AAP45146.1; -; mRNA EMBL; FJ969729; ACT21090.1; -; mRNA EMBL; AK301741; BAG63204.1; -; mRNA EMBL; AL590076; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471075; EAX08219.1; -; Genomic_DNA EMBL; BC128146; AAI28147.1; -; mRNA EMBL; BC128147; AAI28148.1; -; mRNA CCDS; CCDS45013.1; -. [Q6XPS3-5] CCDS; CCDS45014.1; -. [Q6XPS3-1] CCDS; CCDS9285.1; -. [Q6XPS3-3] RefSeq; NP_001135440.1; NM_001141968.1. [Q6XPS3-5] RefSeq; NP_001258779.1; NM_001271850.1. [Q6XPS3-6] RefSeq; NP_570141.3; NM_130785.3. [Q6XPS3-3] RefSeq; NP_954863.2; NM_199254.2. [Q6XPS3-1] UniGene; Hs.377488; - ProteinModelPortal; Q6XPS3; - SMR; Q6XPS3; - BioGrid; 125031; 59 STRING; 9606.ENSP00000372437; - SwissLipids; SLP:000000884; -. [Q6XPS3-3] DEPOD; Q6XPS3; - iPTMnet; Q6XPS3; - PhosphoSitePlus; Q6XPS3; - BioMuta; TPTE2; - DMDM; 215273973; - MaxQB; Q6XPS3; - PaxDb; Q6XPS3; - PeptideAtlas; Q6XPS3; - PRIDE; Q6XPS3; - ProteomicsDB; 67806; - ProteomicsDB; 67807; -. [Q6XPS3-2] ProteomicsDB; 67808; -. [Q6XPS3-3] ProteomicsDB; 67809; -. [Q6XPS3-4] Ensembl; ENST00000255310; ENSP00000255310; ENSG00000132958. [Q6XPS3-3] Ensembl; ENST00000382978; ENSP00000372438; ENSG00000132958. [Q6XPS3-2] Ensembl; ENST00000390680; ENSP00000375098; ENSG00000132958. [Q6XPS3-3] Ensembl; ENST00000400103; ENSP00000382974; ENSG00000132958. [Q6XPS3-5] Ensembl; ENST00000400230; ENSP00000383089; ENSG00000132958. [Q6XPS3-1] GeneID; 93492; - KEGG; hsa:93492; - UCSC; uc001ume.4; human. [Q6XPS3-1] CTD; 93492; - DisGeNET; 93492; - EuPathDB; HostDB:ENSG00000132958.17; - GeneCards; TPTE2; - H-InvDB; HIX0016023; - H-InvDB; HIX0020751; - H-InvDB; HIX0037315; - H-InvDB; HIX0037502; - HGNC; HGNC:17299; TPTE2 HPA; HPA068342; - MIM; 606791; gene neXtProt; NX_Q6XPS3; - OpenTargets; ENSG00000132958; - PharmGKB; PA134917664; - eggNOG; KOG2283; Eukaryota eggNOG; COG2453; LUCA GeneTree; ENSGT00760000119113; - HOGENOM; HOG000049109; - HOVERGEN; HBG084209; - InParanoid; Q6XPS3; - KO; K18079; - OMA; YFWFNTS; - OrthoDB; EOG091G09VG; - PhylomeDB; Q6XPS3; - TreeFam; TF354329; - Reactome; R-HSA-1660514; Synthesis of PIPs at the Golgi membrane GenomeRNAi; 93492; - PRO; PR:Q6XPS3; - Proteomes; UP000005640; Chromosome 13 Bgee; ENSG00000132958; - CleanEx; HS_TPTE2; - ExpressionAtlas; Q6XPS3; baseline and differential GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell GO; GO:0000139; C:Golgi membrane; TAS:Reactome GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IEA:UniProtKB-EC GO; GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; TAS:Reactome GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro GO; GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome Gene3D; 1.20.120.350; -; 1 Gene3D; 3.90.190.10; -; 1 InterPro; IPR000340; Dual-sp_phosphatase_cat-dom InterPro; IPR029021; Prot-tyrosine_phosphatase-like InterPro; IPR014020; Tensin_C2-dom InterPro; IPR029023; Tensin_phosphatase InterPro; IPR016130; Tyr_Pase_AS InterPro; IPR027359; Volt_channel_dom_sf Pfam; PF00782; DSPc; 1 Pfam; PF10409; PTEN_C2; 1 SMART; SM01326; PTEN_C2; 1 SUPFAM; SSF52799; SSF52799; 1 PROSITE; PS51182; C2_TENSIN; 1 PROSITE; PS51181; PPASE_TENSIN; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; Endoplasmic reticulum; Hydrolase; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 522 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 /FTId=PRO_0000224187 TRANSMEM 66 86 Helical. TRANSMEM 111 131 Helical. TRANSMEM 146 166 Helical. DOMAIN 210 386 Phosphatase tensin-type {ECO:0000255|PROSITE-ProRule:PRU00590} DOMAIN 393 522 C2 tensin-type. {ECO:0000255|PROSITE- ProRule:PRU00589} ACT_SITE 320 320 Phosphocysteine intermediate VAR_SEQ 1 329 Missing (in isoform 6) /FTId=VSP_047569 VAR_SEQ 40 170 Missing (in isoform 4) /FTId=VSP_017322 VAR_SEQ 40 77 SMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFG -> R (in isoform 3) /FTId=VSP_017323 VAR_SEQ 60 171 DSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDS KLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFN ILDTAIIVIPLLVDVIYIFFDIKLLRNIPR -> E (in isoform 5) /FTId=VSP_044506 VAR_SEQ 132 171 Missing (in isoform 2 and isoform 3) /FTId=VSP_017324 VAR_SEQ 435 522 ILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCP FFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVE ILFGEK -> REEGSTLRRANWKGEPSRRPVLD (in isoform 4) /FTId=VSP_017325 VAR_SEQ 466 522 NLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAW KIYPPEFAVEILFGEK -> REEGSTLRRANWKGEPSRRPV LD (in isoform 7) /FTId=VSP_053978 VARIANT 367 367 V -> I (in dbSNP:rs2497218) /FTId=VAR_047501 VARIANT 444 444 I -> V (in dbSNP:rs2497218) /FTId=VAR_057349 MUTAGEN 320 320 C->S: Loss of activity CONFLICT 521 521 E -> K (in Ref. 1; CAD13144 and 2; AAP45146). SEQUENCE 522 AA; 61112 MW; 4CC42349355EDA9F CRC64; MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK
Research Areas
Citations (0)

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References

Walker S.M., et al. Biochem. J. 360:277-283(2001).
Tapparel C., et al. Gene 323:189-199(2003).
Dunham A., et al. Nature 428:522-528(2004).
Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
Cat# AM2224a
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(40 western blots)
Availability: In Stock
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