|Application ||WB, FC, IF, E|
|Calculated MW||47916 Da|
|Antigen Region||1-444 aa|
|Other Names||Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3|
|Target/Specificity||This GATA3 antibody is generated from a mouse immunized with a recombinant protein from human GATA3.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GATA3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.|
|Tissue Location||T-cells and endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.
Joulin V.,et al.EMBO J. 10:1809-1816(1991).
Ho I.-C.,et al.EMBO J. 10:1187-1192(1991).
Ko L.J.,et al.Mol. Cell. Biol. 11:2778-2784(1991).
Marine J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991).
Deloukas P.,et al.Nature 429:375-381(2004).
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