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> home > Products > Primary Antibodies > Antibody Collections > Anti-Kinome Antibodies > EPHB2 Antibody
EPHB2 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P29323 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1κ |
| Clone/Animal Names | 48CT12.6.4 |
| Calculated MW | 117493 Da |
| Gene ID | 2048 |
|---|---|
| Other Names | Ephrin type-B receptor 2, Developmentally-regulated Eph-related tyrosine kinase, ELK-related tyrosine kinase, EPH tyrosine kinase 3, EPH-like kinase 5, EK5, hEK5, Renal carcinoma antigen NY-REN-47, Tyrosine-protein kinase TYRO5, Tyrosine-protein kinase receptor EPH-3, EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5 |
| Target/Specificity | Purified His-tagged EPHB2 protein(Fragment, between amino acids 127~425) was used to produce this monoclonal antibody. |
| Dilution | WB~~1:1000 IHC~~1:400 IHC-P~~1:200 FC~~1:10~50 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EPHB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPHB2 |
|---|---|
| Synonyms | DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5 |
| Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite |
| Tissue Location | Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain |
Research Areas
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$ 385.00
Cat# AM7623B
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