|Application ||WB, E|
|Calculated MW||542687 Da|
|Other Names||Protocadherin Fat 4, hFat4, Cadherin family member 14, FAT tumor suppressor homolog 4, Fat-like cadherin protein FAT-J, FAT4, CDHF14, FATJ|
|Target/Specificity||This FAT4 antibody is generated from a mouse immunized with a recombinant protein between 4500-4786 amino acids from human FAT4.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAT4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Note=In the kidney, localizes to primary cilia.|
|Tissue Location||Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).
Hoeng J.C.,et al.J. Mol. Biol. 337:307-317(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Ohira M.,et al.Cancer Lett. 197:63-68(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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