|Application ||WB, E|
|Calculated MW||542687 Da|
|Other Names||Protocadherin Fat 4, hFat4, Cadherin family member 14, FAT tumor suppressor homolog 4, Fat-like cadherin protein FAT-J, FAT4, CDHF14, FATJ|
|Target/Specificity||This FAT4 antibody is generated from a mouse immunized with a recombinant protein between 4500-4786 amino acids from human FAT4.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAT4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Note=In the kidney, localizes to primary cilia.|
|Tissue Location||Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer|
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Provided below are standard protocols that you may find useful for product applications.
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).
Hoeng J.C.,et al.J. Mol. Biol. 337:307-317(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Ohira M.,et al.Cancer Lett. 197:63-68(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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