|Application ||IHC-P, FC, WB, E|
|Calculated MW||285215 Da|
|Other Names||Unconventional myosin-XVIIIb, MYO18B|
|Target/Specificity||This MYO18B antibody is generated from a mouse immunized with recombinant protein from human MYO18B.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYO18B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes|
|Tissue Location||Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus|
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May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Nishioka M.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12269-12274(2002).
Salamon M.,et al.J. Mol. Biol. 326:137-149(2003).
Gu Y.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Dunham I.,et al.Nature 402:489-495(1999).
Stanchi F.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
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