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Phospho-Ser603 Synapsin I Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Phospho-Ser603 Synapsin I  Antibody AN1025
    Western blot of rat cortex lysate showing specific immunolabeling of the ~78k synapsin I phosphorylated at Ser603 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the phospho-Ser603 synapsin I antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17599
Reactivity Rat
Predicted Bovine, Human, Mouse, Xenopus, Zebrafish
Host Rabbit
Clonality polyclonal
Calculated MW 78 KDa
Additional Information
Gene ID 281510
Gene Name SYN1
Other Names Synapsin-1, Synapsin I, SYN1
Target/Specificity Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser603 conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Antibody Specificity Specific for ~78k synapsin I doublet protein phosphorylated at Ser603.Immunolabeling of the synapsin I band is blocked byλ-phosphatase treatment.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Ser603 Synapsin I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
Citations (0)

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Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. Th e role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases (Sakurada et al., 2002; Czernik et al., 1987). Phosphorylation of this site is thought to regulate synaptic vesicle function (Nayak et al., 1996; Bahler and Greengard, 1987; McGuinness et al., 1989).


Bahler M, Greengard P (1987) Synapsin I bundles F-actin
in a phosphorylation-dependent manner. Nature (London)
Czernik AJ, Pang DT, Greengard P (1987) Amino acid
sequences surrounding the cAMP-dependent and
calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. Proc Natl Acad Sci (USA)
Feng J, Chi P, Blanpied TA, Xu YM, Magarinos AM, Fe
rreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA,
Augustine GJ, Greengard P (2002) Regulation of neurotransmitter release by synapsin III. J Neurosci 22:4372-
Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Jr., Gr
eengard P, Czernik AJ (2001) Opposing changes in
phosphorylation of specific sites in synapsin I during Ca
-dependent glutamate release in isolated nerve
terminals. J Neurosci 21:7944-7953.
Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M,
Czernik AJ, Pieribone VA, Poo MM, Greengard P (2002) A
protein kinase A-dependent molecular switch in synapsin
s regulates neurite outgrowth. Nature Neurosci 5:431-
McGuinness TL, Brady ST, Gruner JA, Sugimori M, L
linás RR, Greengard P (1989)
inhibition by synapsin I of organelle movement in squid axoplasm. J Neurosci 9:4138-4149.
Nayak AS, Moore CI, Browning MD (1996) CAM kinase II phos
phorylation of the presyn
aptic protein synapsin is
persistently increased during expression of long-term po
tentiation. Proc Natl Acad Sci (USA) 93:15451-15456.
Sakurada K, Kato H, Nagumo H, Hiraoka H, Furuya K, Ikuhar
a T, Yamakita Y, Fukunaga K, Miyamoto E, Matsumura
F, Matsuo YI, Naito Y, Sasaki Y (2002) Synapsin I is phosphorylated at Ser
by p21-activated kinases (PAKs)
in vitro
and in PC12 cells stimulated with bradykinin. J Biol Chem 277:45473-45479.
Sergio Leal-Ortiz, Clarissa L. Waites, Ryan Terry-Lorenzo
, Pedro Zamorano, Eckart D.
Gundelfinger, and Craig C.
Garner (2008)
Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis
J. Cell Biol., 181:
831 - 846.

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$ 335.00
Cat# AN1025
(40 western blots)
Availability: 7-10 days
Bulk Size
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