|Predicted||Bovine, Human, Mouse, Monkey|
|Calculated MW||82 KDa|
|Other Names||Rabphilin-3A, Exophilin-1, Rph3a|
|Target/Specificity||Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.|
|Format||Prepared from rabbit serum by affinity purification on a column to which the C-terminal peptide immunogen was coupled.|
|Antibody Specificity||Specific for the ~82k rabphilin 3A protein.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Rabphilin 3A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Rabphilin-3A is a peripheral membrane protein that binds Ca 2+ and phospholipids and is attached to synaptic vesicle membranes (Geppert et al., 1994;Li et al., 1994). The expression of rabphilin 3A is reduced in an animal model of Huntington’s disease (Smith et al., 2005). Rabphilin can be phosphorylated at Ser 234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner (Fykse et al., 1995;Foletti and Scheller, 2001).
Foletti DL, Scheller RH (2001) Developmental regulation and specific brain distribution of
phosphorabphilin. J Neurosci 21:5461-5472.
Fykse EM, Li C, Sudhof TC (1995) Phosphorylatio
n of rabphilin-3A by Ca2+/calmodulin- and cAMP-
dependent protein kinases in vitro. J Neurosci 15:2385-2395.
Geppert M, Bolshakov VY, Siegelbaum SA, Takei K,
De Camilli P, Hammer RE, Südhof TC (1994) The
role of Rab3A in neurotransmitter release. Nature (Lond ) 369:493-497.
Li C, Takei K, Geppert M, Daniell L, Stenius K,
Chapman ER, Jahn R, De Camilli P, Südhof TC (1994)
Synaptic targeting of rabphilin
-3A, a synaptic vesicle Ca
/phospholipid- binding protein, depends on
rab3A/3C. Neuron 13:885-898.
Smith R, Petersen A, Bates GP, Brundin P, Li JY (20
05) Depletion of rabphilin 3A in a transgenic mouse
model (R6/1) of Huntington's disease, a possible
culprit in synaptic dysfunction. Neurobiol Dis 20:673-
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