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Synaptotagmin Antibody

Affinity purified rabbit polyclonal antibody

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  • WB - Synaptotagmin Antibody AN1109
    All lanes : Anti-Syt1 Antibody at 1:1000 dilution Lane 1: mouse brain lysate Lane 2: rat brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - Synaptotagmin Antibody AN1109
    Western blot analysis of lysates from rat brain, mouse brain, human brain tissue lysate(from left to right), using Syt1 Antibody(Cat. #AN1109). AN1109 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • WB - Synaptotagmin Antibody AN1109
    Western blot of rat cortex lysate showing specific labeling of the ~65ksynaptotagmin protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21707
Reactivity Human, Mouse, Rat
Predicted Bovine, Chicken, Human, Mouse, Monkey
Host Rabbit
Clonality polyclonal
Calculated MW 65 KDa
Additional Information
Gene ID 25716
Gene Name SYT1
Other Names Synaptotagmin-1, Synaptotagmin I, SytI, p65, Syt1
Target/Specificity Synthetic peptide corresponding to amino acid residues specific to synaptotagmin 1 conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled
Antibody Specificity Specific for ~65k synaptotagmin I protein
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynaptotagmin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release (Littleton and Bellen 1995). Recent studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion (Zhang et al., 2002). It has recently been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size (Poskanzer et al., 2006).


Littleton JT, Bellen HJ (1995) Synaptotagmin controls and modulates synaptic vesicle fusion in a Ca(2+) dependent manner. Trends Neurosci. Apr;18(4):177-83.
Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (2002) Ca2+ dependent synaptotagmin binding to SNAP25 is essential for Ca2+ triggered exocytosis. Neuron May 16;34(4):599-611.
Poskanzer KE, Fetter RD, Davis GW (2006) Discrete residues in the c(2)b domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Neuron Apr 6;50(1):49-62.

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$ 335.00
Cat# AN1109
(40 western blots)
Availability: 7-10 days
Bulk Size
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