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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Amyotrophic Lateral Sclerosis (ALS)   >   NMDA Receptor, NR2A Subunit N-terminus Antibody   

NMDA Receptor, NR2A Subunit N-terminus Antibody

Affinity purified rabbit polyclonal antibody

  • WB - NMDA Receptor, NR2A Subunit N-terminus Antibody AN1150
    Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~ 180k NR2A subunit.
  • IHC - NMDA Receptor, NR2A Subunit N-terminus Antibody AN1150
    Immunostaining of 21 DIV nucleofected mouse striatal neuron (green) co-cultured with cortical neurons showingnice punctate labeling of the N-terminal NR2A subunit (red) in both the medium spiny neurons and the large pyramidalcell in the upper right. Photo courtesy of Dr. A.J. Milnerwood, Dr. Lynn Raymond Lab, University of British Columbia.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q00959
Reactivity Rat
Predicted Bovine, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 180 KDa
Additional Information
Gene ID 24409
Gene Name GRIN2A
Other Names Glutamate receptor ionotropic, NMDA 2A, GluN2A, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a
Target/Specificity Synthetic peptide corresponding to amino acid residues from the N-terminal region of the NR2A subunit conjugated to KLH.
Dilution WB~~ 1:1000
IHC~~ 1:500
Format Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Antibody Specificity Specific for the ~180k NR2A subunit of the NMDA receptor.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNMDA Receptor, NR2A Subunit N-terminus Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
Citations (0)

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The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.


Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD (2003) Tyrosine dephosphorylation and ethanol inhibition of N-methyl-D-aspartate receptor function. J Biol Chem 278:11020-11025.
Carroll RC, Zukin RS (2002) NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 25:571-577.
Grosshans DR, Clayton DA, Coultrap SJ, Browning MD (2002) LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 5:27-33.
Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:1721-1724.
Lu W-Y, Xiong Z-G, Lei S, Orser BA, Browning MD, MacDonald JF (1999) G-protein coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nature Neurosci 2:331-338.
Snell LD, Nunley KR, Lickteig RL, Browning MD, Tabakoff B, Hoffman PL (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Mol Brain Res 40:71-78.
Wenthold RJ, Prybylowski K, Standley S, Sans N, Petralia RS (2003) Trafficking of NMDA receptors. Annu Rev Pharmacol Toxicol 43:335-358.

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$ 335.00
Cat# AN1150
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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