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Norepinephrine Transporter Antibody

Mouse monoclonal antibody

  • WB - Norepinephrine Transporter Antibody AN1168
    Western blot of rat cortex homogenate showing specific immunolabelingof the ~ 55k norepinephrine transporter protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O55192
Reactivity Mouse, Rat
Host Mouse
Clonality monoclonal
Isotype IgG2b
Clone Names NET-05
Calculated MW 55 KDa
Additional Information
Gene ID Mm.57040
Gene Name SLC6A2
Other Names Sodium-dependent noradrenaline transporter, Norepinephrine transporter, NET, Solute carrier family 6 member 2, Slc6a2
Target/Specificity Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.
Dilution WB~~ 1:2000
Format Protein G purified culture supernatant.
Antibody Specificity Specific for the ~55kDa Norepinephrine Transporter in Western blots ofmouse and rat cortex homogenate. No reactivity with tissue or cells from NET knock-out mice.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNorepinephrine Transporter Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006).


Klimek V, Stockmeier C, Overholser J, Meltzer HY, Kalka S, Dilley G, Ordway GA (1997)
Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J.
Neurosci. 17(21):8451-8458
Kim CH, Hahn MK, Joung Y, Anderson SL, Steele AH, Mazei-Robinson MS, Gizer I, Teicher
MH, Cohen BM, Robertson D, Waldman ID, Blakely RD, Kim KS (2006) A Polymorphism in the
norepinephrine transporter gene alters promoter activity and is associated with attention-deficit
hyperactivity disorder. Proc Nat’l Acad Sci USA 103(50):19164-9.

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$ 335.00
Cat# AN1168
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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