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DsbA-L Antibody

Rabbit polyclonal antibody

     
  • WB - DsbA-L Antibody AN1188
    Western blot of mouse adipose tissue showing specificimmunolabeling of the ~ 25k DsbA-L protein.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9DCM2
Host Rabbit
Clonality polyclonal
Calculated MW 25 KDa
Additional Information
Target/Specificity Full length recombinant mouse DsbA-L protein.
Dilution WB~~ 1:2000
Format serum
Antibody Specificity Specific for the ~25 kDa DsbA-L protein in Western blots of 3T3-L1adipocytes and mouse white and brown adipose tissue lysate samples. It is suggested that youadd 1% BSA to the antibody dilution buffer.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDsbA-L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
Citations (0)

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Background

Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution (Gao F et al., 2009). Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis (Liu et al., 2008).

References

Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in
Chinese population. (2009) Gao F, Fang Q, Zhang R, Lu J, Lu H, Wang C, Ma X, Xu J, Jia W,
Xiang K. Endocr J. Jun;56(3):487-94.
Liu et al, (2008) A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin
multimerization. Proc Natl Acad Sci USA, 105, 18302-18307.
Wang A, Liu M, Liu X, Dong LQ, Glickman RD, Slaga TJ, Zhou Z, Liu F (2011) Up-regulation of
Adiponectin by Resveratrol: THE ESSENTIAL ROLES OF THE Akt/FOXO1 AND AMPACTIVATED
PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L. J Biol Chem. Jan
7;286(1):60-6.

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$ 285.00
Cat# AN1188
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