|Reactivity||Bovine, Human, Hamster, Mouse, Pig, Rat, Rabbit|
|Calculated MW||16 KDa|
|Other Names||Vesicle-associated membrane protein 1, VAMP-1, Synaptobrevin-1, VAMP1, SYB1|
|Target/Specificity||Synaptic immunoprecipitate (crude) from human brain.|
|Format||Purified culture supernatant.|
|Antibody Specificity||The antibody is specific for the ~16kDa synaptobrevin protein inWestern blots of rat brain lysate. The antibody has also been demonstrated to work inimmunohistochemistry on formalin fixed, vibratome sections, but does not work on paraffinsections.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Synaptobrevin (VAMP) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in hum an hippocampus and cortex have been correlated with cognitive defects in Alzheimer’s disease (Sze et al., 2000)
(2004) Synaptobrevin is essential for fast
Nat Cell Biol.
Sze CI, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ (2000)
Selective regional loss of
exocytotic presynaptic vesicle proteins in Alzheimer's disease brains.
J Neurol Sci.175(2):81-90.
Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in
cerebellum and visual cortex (1993).
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