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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Phospho Antibodies   >   Synaptobrevin (VAMP) Antibody   

Synaptobrevin (VAMP) Antibody

Mouse monoclonal antibody

  • WB - Synaptobrevin (VAMP)  Antibody AN1195
    Western blot of rat brain lysate showing specific immunolabelingof the ~ 16k synaptobrevin protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23763
Reactivity Bovine, Human, Hamster, Mouse, Pig, Rat, Rabbit
Host Mouse
Clonality monoclonal
Isotype IgM
Clone Names SP10
Calculated MW 16 KDa
Additional Information
Gene ID 6843
Gene Name VAMP1/2
Other Names Vesicle-associated membrane protein 1, VAMP-1, Synaptobrevin-1, VAMP1, SYB1
Target/Specificity Synaptic immunoprecipitate (crude) from human brain.
Dilution WB~~ 1:1000
Format Purified culture supernatant.
Antibody Specificity The antibody is specific for the ~16kDa synaptobrevin protein inWestern blots of rat brain lysate. The antibody has also been demonstrated to work inimmunohistochemistry on formalin fixed, vibratome sections, but does not work on paraffinsections.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynaptobrevin (VAMP) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in hum an hippocampus and cortex have been correlated with cognitive defects in Alzheimer’s disease (Sze et al., 2000)


Deák F
Schoch S
Liu X
Südhof TC
Kavalali ET
(2004) Synaptobrevin is essential for fast
synaptic-vesicle endocytosis.
Nat Cell Biol.
2004 Nov;6(11):1102-8.
Sze CI, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ (2000)
Selective regional loss of
exocytotic presynaptic vesicle proteins in Alzheimer's disease brains.
J Neurol Sci.175(2):81-90.
Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in
cerebellum and visual cortex (1993).
Brain Research
, 9-20.

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$ 335.00
Cat# AN1195
(40 western blots)
Availability: 7-10 days
Bulk Size
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