|Reactivity||Human, Hamster, Pig, Rat|
|Calculated MW||36 KDa|
|Other Names||Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1|
|Target/Specificity||Synaptic immunoprecipitate (crude) from human brain.|
|Format||Protein G purified culture supernatant.|
|Antibody Specificity||The antibody is specific for the ~ 36 kDa syntaxin protein in Westernblots of rat brain lysate. The antibody has also been used for immunohistochemistry on formalinfixed, vibratome sections. Does not work on paraffin sections.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Syntaxin 1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).
(2007) Dual modes of Munc18-
1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.
2007 Nov 7;27(45):12147-55
(2010) Deficits in syntaxin 1
phosphorylation in schizophrenia prefrontal cortex.
Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in
cerebellum and visual cortex.
609, 9-20 (1993).
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