|Application ||WB, FC, IF|
|Reactivity||Bovine, Human, Mouse, Rat|
|Calculated MW||21 KDa|
|Other Names||Protein DJ-1, 34--, Contraception-associated protein 1, Protein CAP1, Fertility protein SP22, Parkinson disease protein 7 homolog, Park7, Cap1|
|Target/Specificity||Full length recombinant human Park7 expressed in and purified from E. coli.|
|Format||Affinity purified from tissue culture supernatant|
|Antibody Specificity||Specific for the ~21k park7 protein|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Park7 (DJ-1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Park7, also known as DJ-1, is a member of the peptidase C56 family of proteins and is thought to function as a molecular chaperone. Mutations in park7 have been associated with autosomal recessive, early onset Parkinson’s disease (Bonifati et al., 2003). Recently, park7 has been shown to inhibit microtubule associated protein 1B aggregation thus leading to neuronal apoptosis (Wang et al., 2011).
Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. Jan 10;299(5604):256-9
Wang Z, Zhang Y, Zhang S, Guo Q, Tan Y, Wang X, Xiong R, Ding J, Chen S. (2011) DJ-1 can inhibit microtubule associated protein 1 B formed aggregates. Mol Neurodegener. Jun 6;6:38
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