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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Phospho Antibodies   >   Alpha II Spectrin Antibody   

Alpha II Spectrin Antibody

Mouse monoclonal antibody

  • WB - Alpha II Spectrin Antibody AN1218
    Western blot of rat hippocampal lysate showing specific immunolabeling of the ~240k alpha II spectrin protein.
  • IF - Alpha II Spectrin Antibody AN1218
    Immunofluorescence of cultured rat neurons and glia showing axonal and dendritic staining of alpha II spectrin (green) revealing the submembraneous cytoskeleton and DNA (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13813
Reactivity Bovine, Human, Rat
Host Mouse
Clonality monoclonal
Isotype IgG1
Clone Names 3D7
Calculated MW 240 KDa
Additional Information
Gene Name SPTAN1
Other Names Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit, SPTAN1, NEAS, SPTA2
Target/Specificity Recombinant contstruct containing the 7th, 8th, 9th repeats of human alpha II spectrin.
Dilution WB~~ 1:3000
IF~~ 1:500
Format Affinity purified from tissue culture supernatant.
Antibody Specificity Specific for the ~240 k alpha II spectrin protein.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAlpha II Spectrin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
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The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (α1 and α2) and five beta genes (β1-β5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).


Bennett V & Baines AJ.(2001) Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev. 81:1353-92.
Eber S & Lux SE. (2004) Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer. Semin Hematol 41:118-41.

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$ 335.00
Cat# AN1218
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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