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MCP-1 Antibody

Purified Mouse Monoclonal Antibody

  • WB - MCP-1 Antibody AO1014a
    Figure 1: Western blot analysis using MCP1 mouse mAb against truncated MCP-1 recombinant protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13500
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1A7B8
Isotype IgG1.kappa
Calculated MW 11025 Da
Description Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
Immunogen Purified recombinant fragment of human MCP-1 expressed in E. Coli.
Formulation Purified antibody in PBS containing 0.03% sodium azide.
Additional Information
Gene ID 6347
Other Names C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2, CCL2, MCP1, SCYA2
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMCP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCL2
Synonyms MCP1, SCYA2
Function Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Cellular Location Secreted.
Research Areas
Citations (0)

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1. Yoshimura T. et al. 1989. FEBS Lett. 244:487-493. 2. Yoshimura T. et al. 1991. Adv. Exp. Med. Biol. 305:47-56. 3. Rollins B.J. et al. 1991. Genomics. 10:489-492.

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$ 300.00
Cat# AO1014a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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