|Application ||WB, E|
|Calculated MW||93985 Da|
|Description||Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV ORF8 is a virion envelope-associated protein. Akula et al (2003) report it acts as a Glycoprotein B mediated signaling during virus entry. This Glycoprotein possesses the Arg-Gly-Asp (RGD) motif and utilizes alpha3beta1 integrin as one of the receptors for its entry into the target cells.|
|Immunogen||Synthetic peptide, corresponding to amino acids sequence of KSHV ORF8. |
|Other Names||Envelope glycoprotein B, gB, ORF8|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KSHV ORF8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Envelope glycoprotein that forms spikes at the surface of the virion envelope. Participates in viral entry through an RGD motif that binds ITGAV-ITGB3. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.|
|Cellular Location||Virion membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
1. James J. Proc. Natl. Acad. Sci Vol. 1993, pp. 14862-14867. 2. Wang FZ. J Virol. 2003 Mar; 77(5):3131-47.
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