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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KSHV ORF8 Antibody   

KSHV ORF8 Antibody

Purified Mouse Monoclonal Antibody

  • WB - KSHV ORF8 Antibody AO1038a
    Figure 1: Western blot analysis using anti-KSHV ORF8 polyclonal antiobdy against uninduced BCBL1 cell lysate (1), TPA induced BCBL1 cell lysate(2) and purified virion (3).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession F5HB81
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names N/A
Calculated MW 93985 Da
Description Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV ORF8 is a virion envelope-associated protein. Akula et al (2003) report it acts as a Glycoprotein B mediated signaling during virus entry. This Glycoprotein possesses the Arg-Gly-Asp (RGD) motif and utilizes alpha3beta1 integrin as one of the receptors for its entry into the target cells.
Immunogen Synthetic peptide, corresponding to amino acids sequence of KSHV ORF8.
Formulation Rabbit anti-serum.
Additional Information
Gene ID 4961501
Other Names Envelope glycoprotein B, gB, ORF8
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKSHV ORF8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORF8
Function Envelope glycoprotein that forms spikes at the surface of the virion envelope. Participates in viral entry through an RGD motif that binds ITGAV-ITGB3. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
Cellular Location Virion membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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1. James J. Proc. Natl. Acad. Sci Vol. 1993, pp. 14862-14867. 2. Wang FZ. J Virol. 2003 Mar; 77(5):3131-47.

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$ 300.00
Cat# AO1038a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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