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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Fibulin 5 Antibody   

Fibulin 5 Antibody

Purified Mouse Monoclonal Antibody

  • WB - Fibulin 5 Antibody AO1062a
    Figure 1: Western blot analysis using Fibulin5 mouse mAb against truncated fibulin5 recombinant protein (1) and Hela cell lysate (2).
  • IHC - Fibulin 5 Antibody AO1062a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human stomach carcinoma (left) and breast carcinoma (right), showing cytoplasmic localization using fibulin5 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBX5
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3F10A5; 3F8A12
Isotype IgG1
Calculated MW 50180 Da
Description Fibulin 5(FBLN5), with 448-amino acid protein (about 50kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Immunogen Purified recombinant fragment of Fibulin 5 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 10516
Other Names Fibulin-5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50, FBLN5, DANCE
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFibulin 5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBLN5
Synonyms DANCE
Function Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823).
Cellular Location Secreted Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.
Tissue Location Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).
Research Areas
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1. Wen Wang , Scott A. LeMaire, Li Chen. Surgery. 2005 Aug;138(2):352-9 2. K. Kadoya, T. Sasaki, G. Kostka. Br J Dermatol. 2005 Sep;153(3):607-123. 3. Michael J. Lee, Nakshatra K. Roy, Jon E. Mogford. J Am Coll Surg. 2004 Sep;199(3):403-10.

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$ 385.00
Cat# AO1062a
(40 western blots)
Availability: 7-10 days
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