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CK1 Antibody

Purified Mouse Monoclonal Antibody

  • WB - CK1 Antibody AO1069a
    Figure 1: Western blot analysis using CK1 mouse mAb against truncated CK1 recombinant protein.
  • IHC - CK1 Antibody AO1069a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human liver tissue (A), colon carcinoma (B), lung carcinoma (C) and esophagus tissue (D), showing membrane localization using CK1 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04264
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3C10F7; 3C10G5; PMC01; 4D12B3; 3C10F7C11
Isotype IgG1
Calculated MW 66039 Da
Description CK1 (also designated Cytokeratin 1 or KRT1 ),with 644-amino acid protein (about 70kDa), is a member of the keratin family. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells.CK1 consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. CK1 is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma.
Immunogen Purified recombinant fragment of CK1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3848
Other Names Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, CK-1, Hair alpha protein, Keratin-1, K1, Type-II keratin Kb1, KRT1, KRTA
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT1
Synonyms KRTA
Function May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Cellular Location Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells
Tissue Location The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis
Research Areas
Citations (0)

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1. Ricardo G. Espinola, Robin A. Pixley, Berhane Ghebrehiwet. Blood (ASH Annual Meeting Abstracts), Nov 2005; 106: 2666.

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$ 300.00
Cat# AO1069a
(40 western blots)
Availability: 7-10 days
Bulk Size
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