|Application ||WB, IHC, E|
|Calculated MW||17184 Da|
|Description||Myoglobin (MB), with 154-amino acid protein (about 17kDa), is a member of the globin superfamily and expression of myoglobin is highest in skeletal and cardiac muscle. Functionally, myoglobin is well accepted as an O2-storage protein in muscle, capable of releasing O2 during periods of hypoxia or anoxia. Myoglobin is also thought to buffer intracellular O2 concentration when muscle activity increases and to facilitate intracellular O2 diffusion by providing a parallel path that augments simple diffusion of dissolved O2. Furthermore, myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis.|
|Immunogen||Purified recombinant fragment of Myoglobin expressed in E. Coli.|
|Formulation||Purified antibody in PBS containing 0.03% sodium azide.|
|Other Names||Myoglobin, MB|
|Dilution||WB~~1/500 - 1/2000|
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Myoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.|
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Provided below are standard protocols that you may find useful for product applications.
1. George A. Ordway, Daniel J. Garry. J. Exp. Biol., Sep 2004; 207: 3441-3446. 2. Ulrich Floel, Tim Laussmann, Axel Goecke. Circ. Res., Apr 2005; 96: e68 - e75.
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