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LPP Antibody

Purified Mouse Monoclonal Antibody

  • WB - LPP Antibody AO1148a
    Figure 1: Western blot analysis using LPP mouse mAb against Hela (1), NIH/3T3 (2), COS (3), Caki (4), MCF-7 (5), HepG2 (6) and SMMC-7721 (7) cell lysate.
  • IHC - LPP Antibody AO1148a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human small intestine using LPP mouse mAb with DAB staining.
  • IHC - LPP Antibody AO1148a
    Figure 3: Immunohistochemical analysis of paraffin-embedded human vessels tissues using LPP mouse mAb.
  • IF - LPP Antibody AO1148a
    Figure 4: Confocal immunofluorescence analysis of COS cells using LPP mouse mAb (green). Red: Actin filaments have been labeled using DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
  • IF - LPP Antibody AO1148a
    Figure 5: Confocal immunofluorescence analysis of Hela cells using LPP mouse mAb (green). Red: Actin filaments have been labeled using DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q93052
Reactivity Human, Mouse, Hamster, Monkey
Host Mouse
Clonality Monoclonal
Clone Names 8B3A11
Isotype IgG1
Calculated MW 66kDa
Description LIM domain containing preferred translocation partner in lipoma. The Zyxin family of proteins contains five members, Ajuba, LIMD1, LPP,TRIP6 and Zyxin. LPP (LIM-containing lipoma-preferred partner), a LIM domain-containing scaffolding protein contains three LIM domains at its carboxyterminus, which are preceded by a proline-rich pre-LIM region containing a number of protein interaction domains. LPP, an 80 kDa protein, localizes to sites of cell adhesion, such as focal adhesions and cell-cell contacts,and shuttles to the nucleus where it has transcriptional activation capacity.The human LPP gene maps to chromosomal location 3q28, and preferentiallytranslocates to the HMGIC gene in a subclass of human benign mesenchymal tumors known as lipomas.
Immunogen Purified recombinant fragment of human LPP expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 4026
Other Names Lipoma-preferred partner, LIM domain-containing preferred translocation partner in lipoma, LPP
Dilution WB~~1/500 - 1/2000
IHC~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLPP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LPP
Function May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
Cellular Location Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1
Tissue Location Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes
Research Areas
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1. BMC Cell Biol. 2005 Jan 13;6(1):1 2. Mol Cell Proteomics. 2005 Sep;4(9):1240-50. Epub 2005 Jun 11. 3. Cancer Genet Cytogenet. 2005 Nov;163(1):68-70.

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$ 385.00
Cat# AO1148a
(40 western blots)
Availability: 7-10 days
Bulk Size
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