|Application ||WB, IHC, E|
|Calculated MW||58254 Da|
|Description||FRK: fyn-related kinase. The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.|
|Immunogen||Purified recombinant fragment of FRK (aa2-300) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide. |
|Other Names||Tyrosine-protein kinase FRK, 18.104.22.168, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK|
|Dilution||WB~~1/500 - 1/2000|
IHC~~1/500 - 1/2000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FRK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery|
|Tissue Location||Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.|
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1. Int J Cancer. 1993 Jun 19;54(4):571-7. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Neurosci Lett. 2004 Apr 22;360(1-2):109-11.
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