Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
FRK Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P42685 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1A8H2C12 |
| Isotype | IgG1 |
| Calculated MW | 58254 Da |
| Description | FRK: fyn-related kinase. The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. |
| Immunogen | Purified recombinant fragment of FRK (aa2-300) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 2444 |
|---|---|
| Other Names | Tyrosine-protein kinase FRK, 2.7.10.2, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK |
| Dilution | WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FRK Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FRK |
|---|---|
| Synonyms | PTK5, RAK |
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery |
| Tissue Location | Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
1. Int J Cancer. 1993 Jun 19;54(4):571-7. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Neurosci Lett. 2004 Apr 22;360(1-2):109-11.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
