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FRK Antibody

Purified Mouse Monoclonal Antibody

  • WB - FRK Antibody AO1194a
    Figure 1: Western blot analysis using FRK mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY FRK cDNA (2).
  • WB - FRK Antibody AO1194a
    Figure 2: Western blot analysis using FRK mouse mAb against truncated FRK-His recombinant protein (1).
  • IHC - FRK Antibody AO1194a
    Figure 3: Immunohistochemical analysis of paraffin-embedded human Breast tissues using FRK mouse mAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42685
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1A8H2C12
Isotype IgG1
Calculated MW 58254 Da
Description FRK: fyn-related kinase. The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.
Immunogen Purified recombinant fragment of FRK (aa2-300) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 2444
Other Names Tyrosine-protein kinase FRK,, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK
Dilution WB~~1/500 - 1/2000
IHC~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFRK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FRK
Synonyms PTK5, RAK
Function Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery
Tissue Location Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Research Areas
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1. Int J Cancer. 1993 Jun 19;54(4):571-7. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Neurosci Lett. 2004 Apr 22;360(1-2):109-11.

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$ 300.00
Cat# AO1194a
(40 western blots)
Availability: 7-10 days
Bulk Size
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