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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ERBB3 Antibody   

ERBB3 Antibody

Purified Mouse Monoclonal Antibody

  • WB - ERBB3 Antibody AO1206a
    Figure 1: Western blot analysis using ERBB3 mouse mAb against truncated Trx-ERBB3 recombinant protein (1) and MBP-ERBB3 (aa1175-1275) recombinant protein (2).
  • IHC - ERBB3 Antibody AO1206a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebra (left) and breast carcinoma tissue (right),showing cytoplasmic and membrane location with DAB staining using ERBB3 mouse mAb.
  • ICC - ERBB3 Antibody AO1206a
    Figure 2: Confocal immunofluorescence analysis of Hela cells using HDAC3 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin.
  • IF - ERBB3 Antibody AO1206a
    Figure 2: Confocal immunofluorescence analysis of Hela cells using anti-HDAC3 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21860
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3F10F6
Isotype IgG1
Calculated MW 148098 Da
Description ERBB3: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Immunogen Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 2065
Other Names Receptor tyrosine-protein kinase erbB-3,, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsERBB3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERBB3
Synonyms HER3
Function Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Epithelial tissues and brain.
Research Areas
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1. Cancer Sci. 2007 Sep;98(9):1498-503. 2. Breast Cancer Res. 2008;10(1):R2.

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$ 325.00
Cat# AO1206a
(40 western blots)
Availability: 7-10 days
Bulk Size
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