|Application ||WB, E|
|Clone Names||9B12G7; 4D8B12; 9B12D9; 9C11A5|
|Calculated MW||83869 Da|
|Description||Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils.|
|Immunogen||Purified recombinant fragment of MPO (aa1-193) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Myeloperoxidase, MPO, 188.8.131.52, Myeloperoxidase, 89 kDa myeloperoxidase, 84 kDa myeloperoxidase, Myeloperoxidase light chain, Myeloperoxidase heavy chain, MPO|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Myeloperoxidase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.|
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1. J Pediatr Hematol Oncol. 2007 May;29(5):293-7. 2. PLoS ONE. 2008 Jun 30;3(7):e2816.
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