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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ISL1 Antibody   

ISL1 Antibody

Mouse Monoclonal Antibody to ISL1

  • WB - ISL1 Antibody AO1276b
    Figure 1: Western blot analysis using ISL1 mouse mAb against full-length ISL1 (aa1-349)-hIgGFc transfected HEK293 cell lysate(1).
  • ICC - ISL1 Antibody AO1276b
    Figure 2: Confocal immunofluorescence analysis of HEK293 cells trasfected with full-length ISL1-hIgGFc using ISL1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
  • IF - ISL1 Antibody AO1276b
    Figure 2: Confocal immunofluorescence analysis of HEK293 cells trasfected with full-length ISL1-hIgGFc using anti-ISL1 monoclonal antioby (green). Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61371
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B1
Isotype Mouse IgG1
Calculated MW 39036 Da
Description ISL1 (ISL1 transcription factor, LIM/homeodomain) is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. It is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Mutations in this gene have been associated with maturity-onset diabetes of the young.
Immunogen Purified recombinant fragment of human ISL1 expressed in E. Coli.
Additional Information
Gene ID 3670
Other Names Insulin gene enhancer protein ISL-1, Islet-1, ISL1
Target/Specificity Purified recombinant fragment of human ISL1 expressed in E. Coli.
Dilution WB~~1:500~~2000
Format Ascitic fluid containing 0.03% sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsISL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ISL1
Function Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain
Research Areas
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1. Cell. 1996 Jan 26;84(2):309-20.

2. J Neurosci. 2008 Mar 26;28(13):3291-7.

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$ 325.00
Cat# AO1276b
(40 western blots)
Availability: 7-10 days
Bulk Size
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