|Application ||WB, E|
|Description||FRK (Fyn-related kinase), also known as Rak. It is an epithelial tissue-specific kinase. The human FRK gene maps to chromosome 6q21-q22.3 and encodes a 505 amino acid protein. The protein belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.|
|Immunogen||Purified recombinant fragment of human FRK expressed in E. Coli.|
|Formulation||Antibody are purified by protein G affinity chromatography. |
Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
|Other Names||Tyrosine-protein kinase FRK, 220.127.116.11, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FRK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery|
|Tissue Location||Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.|
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Provided below are standard protocols that you may find useful for product applications.
1. Cell Growth Differ. 1994 Dec;5(12):1347-55. 2. Int J Cancer. 2003 Mar 20;104(2):139-46.
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