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FRK Antibody
Purified Mouse Monoclonal Antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | P42685 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4E1 |
| Isotype | IgG1 |
| Calculated MW | 58kDa |
| Description | FRK (Fyn-related kinase), also known as Rak. It is an epithelial tissue-specific kinase. The human FRK gene maps to chromosome 6q21-q22.3 and encodes a 505 amino acid protein. The protein belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. |
| Immunogen | Purified recombinant fragment of human FRK expressed in E. Coli. |
| Formulation | Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50% glycerol and 0.03% sodium azide. |
| Gene ID | 2444 |
|---|---|
| Other Names | Tyrosine-protein kinase FRK, 2.7.10.2, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK |
| Dilution | WB~~1/500 - 1/2000 IHC~~1:200~~1000 IF~~1:200~1000. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FRK Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FRK |
|---|---|
| Synonyms | PTK5, RAK |
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery |
| Tissue Location | Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Cell Growth Differ. 1994 Dec;5(12):1347-55. 2. Int J Cancer. 2003 Mar 20;104(2):139-46.
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$ 325.00
Cat# AO1315a
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