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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FRK Antibody   

FRK Antibody

Purified Mouse Monoclonal Antibody

  • WB - FRK Antibody AO1315a
    Figure 1: Western blot analysis using FRK mouse mAb against K562 cell lysate (1).
  • IHC - FRK Antibody AO1315a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human normal stomach (A), normal liver (B), normal kidney (C) and rectum cancer tissues (D) using WNT10B mouse mAb with DAB staining.
  • IF - FRK Antibody AO1315a
    Figure 3: Confocal immunofluorescence analysis of PANC-1 cells using anti-WNT10B mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42685
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4E1
Isotype IgG1
Calculated MW 58kDa
Description FRK (Fyn-related kinase), also known as Rak. It is an epithelial tissue-specific kinase. The human FRK gene maps to chromosome 6q21-q22.3 and encodes a 505 amino acid protein. The protein belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.
Immunogen Purified recombinant fragment of human FRK expressed in E. Coli.
Formulation Antibody are purified by protein G affinity chromatography.
Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Additional Information
Gene ID 2444
Other Names Tyrosine-protein kinase FRK,, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFRK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FRK
Synonyms PTK5, RAK
Function Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery
Tissue Location Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Research Areas
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1. Cell Growth Differ. 1994 Dec;5(12):1347-55. 2. Int J Cancer. 2003 Mar 20;104(2):139-46.

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$ 325.00
Cat# AO1315a
(40 western blots)
Availability: 7-10 days
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