|Application ||WB, E|
|Description||NKX2.5: NK2 transcription factor related, locus 5 (Drosophila), also known as CSX. It is a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.|
|Immunogen||Purified recombinant fragment of human NKX2.5 expressed in E. Coli.|
|Formulation||Antibody are purified by protein G affinity chromatography. |
Liquid in PBS containing 0.03% sodium azide.
|Other Names||Homeobox protein Nkx-2.5, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, NKX2-5, CSX, NKX2.5, NKX2E|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKX2.5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CSX, NKX2.5, NKX2E|
|Function||Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.|
|Tissue Location||Expressed only in the heart.|
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1. Stem Cells Dev. 2005 Aug;14(4):425-39. 2. Cancer Res. 2003 Sep 1;63(17):5329-34. 3. Circ J. 2002 Jun;66(6):561-3.
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