|Application ||WB, IHC, E|
|Description||CER1: cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis). Ii is a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.|
|Immunogen||Purified recombinant fragment of human CER1 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Cerberus, Cerberus-related protein, DAN domain family member 4, CER1, DAND4|
|Dilution||WB~~1/500 - 1/2000|
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CER1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).|
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1. Dev Biol. 1998 Feb 15;194(2):135-51. 2. Growth Factors. 2004 Dec;22(4):233-41. 3. PLoS One. 2009;4(4):e5302.
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