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Androgen receptor AntibodyMouse Monoclonal Antibody to Androgen receptor
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AO1343a | 0.1ml 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
Androgen receptor Antibody - Product info | |
| Application | WB
|
| Primary Accession | P10275 |
| Other Accession | NP_001011645.1 |
| Reactivity | Human |
| Isotype | Mouse IgG1 |
| Clone Names | 2H8 |
| Calculated MW | 98989 Da |
Androgen receptor Antibody - Additional info | |
| Gene ID 367 | |
| Other Names NR3C4; KD; AIS; SMAX1; HUMARA; AR | |
| Target/Specificity Purified recombinant fragment of human AR expressed in E. Coli. | |
| Dilution WB~~1:500 - 2000. | |
| Format Purified recombinant fragment of human AR expressed in E. Coli. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Androgen receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Androgen receptor Antibody - Protein Information | |
| Name AR | |
| Synonyms DHTR, NR3C4 | |
| Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | |
| Cellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1 | |
| Tissue Location Isoform 2 is mainly expressed in heart and skeletal muscle | |
Androgen receptor Antibody - Related products
AP2509a: Androgen Receptor (ANDR) Antibody
AP10111c: AR Antibody (Center)
AP13058c: AR Antibody (Center)
AP13255c: AR Antibody (Center)
BP10111c: AR Antibody (Center) Blocking peptide
Androgen receptor Antibody - Application data
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Figure 1: Western blot analysis using Androgen receptor mouse mAb against K562 (1), Jurkat (2) and LNCaP (3) cell lysate.
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Figure 2: Western blot analysis using Androgen receptor mouse mAb against human recombinant Androgen receptor.
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Figure 3: Western blot analysis using Androgen receptor mouse mAb against Androgen receptor (aa221-321)-hIgGFc transfected HEK293 cell lysate.
Androgen receptor Antibody - Research Areas
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BACKGROUND
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA binding transcription factor which regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype.
REFERENCES
1. Chin Med J (Engl). 2009 Nov 20;122(22):2779-83.
2. Taiwan J Obstet Gynecol. 2009 Sep;48(3):262-7.
3. Prostate. 2008 Mar 1;68(4):453-61.
4. Cancer Res. 2007 May 15;67(10):4630-7.
