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EGR1 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - EGR1 Antibody AO1382a
    Figure 1: Western blot analysis using EGR1 mouse mAb against EGR1(AA: 282-433)-hIgGFc transfected HEK293 (1)cell lysate.
  • IHC - EGR1 Antibody AO1382a
    Figure 3: Immunohistochemical analysis of paraffin-embedded human Uterus tissues using MUM1 mouse mAb
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P18146
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8A6
Isotype IgG1
Calculated MW 57.5kDa
Description The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
Immunogen Purified recombinant fragment of human EGR1(aa282-433) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 1958
Other Names Early growth response protein 1, EGR-1, AT225, Nerve growth factor-induced protein A, NGFI-A, Transcription factor ETR103, Transcription factor Zif268, Zinc finger protein 225, Zinc finger protein Krox-24, EGR1, KROX24, ZNF225
Dilution WB~~1/500 - 1/2000
IHC~~1:200~~1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEGR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EGR1
Synonyms KROX24, ZNF225 {ECO:0000303|PubMed:21103
Function Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double- stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).
Cellular Location Nucleus. Cytoplasm
Tissue Location Detected in neutrophils (at protein level).
Research Areas
Citations (0)

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References

1. J Mol Biol. 2009 Nov 20;394(1):29-45. 2. Clin Chim Acta. 2010 Jan;411(1-2):67-71. 3. Gene. 2010 Jan 15;450(1-2):121-7.

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$ 300.00
Cat# AO1382a
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