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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KLHL21 Antibody   

KLHL21 Antibody

Purified Mouse Monoclonal Antibody

  • WB - KLHL21 Antibody AO1416a
    Figure 1: Western blot analysis using KLHL21 mAb against human KLHL21 (AA: 250-597) recombinant protein. (Expected MW is 64.4 kDa)
  • IHC - KLHL21 Antibody AO1416a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human brain tissues using KLHL21 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UJP4
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2H4
Isotype IgG1
Calculated MW 66kDa
Description Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Immunogen Purified recombinant fragment of human KLHL21 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 9903
Other Names Kelch-like protein 21, KLHL21, KIAA0469
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLHL21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL21
Synonyms KIAA0469
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Cellular Location Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region
Research Areas
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1. DNA Res. 1997 Oct 31;4(5):345-9. 2. DNA Res. 2005;12(2):117-26. 3. J Cell Biol. 2009 Dec 14;187(6):791-800.

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$ 325.00
Cat# AO1416a
(40 western blots)
Availability: 7-10 days
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