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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HK1 Antibody   

HK1 Antibody

Purified Mouse Monoclonal Antibody

  • WB - HK1 Antibody AO1437a
    Figure 1: Western blot analysis using HK1 mouse mAb against Jurkat (1), Hela (2), HepG2 (3), MCF-7 (4) and PC-12 (5) cell lysate.
  • IHC - HK1 Antibody AO1437a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human salivary gland tissues (left) and kidney tissues (right) using HK1 mouse mAb with DAB staining.
  • IF - HK1 Antibody AO1437a
    Figure 3: Immunofluorescence analysis of NIH/3T3 cells using HK1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19367
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 7A7
Isotype IgG1
Calculated MW 102kDa
Description The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines.
Immunogen Purified recombinant fragment of human HK1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3098
Other Names Hexokinase-1,, Brain form hexokinase, Hexokinase type I, HK I, HK1
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HK1
Cellular Location Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding
Tissue Location Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific
Research Areas
Citations (0)

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1. Cell. 2005 Sep 23;122(6):957-68. 2. J Biomed Sci. 2007 Mar;14(2):195-202. 3. J Neural Transm. 2009 Mar;116(3):275-89.

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$ 325.00
Cat# AO1437a
(40 western blots)
Availability: 7-10 days
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