|Application ||WB, ICC, E|
|Description||The mammalian Kelch like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin organizing proteins. Based on the presence of anti sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.Tissue specificity: Highly expressed in brain.|
|Immunogen||Purified recombinant fragment of human KLHL1 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Kelch-like protein 1, KLHL1, KIAA1490|
|Dilution||WB~~1/500 - 1/2000|
IF~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLHL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in organizing the actin cytoskeleton of the brain cells.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Highly expressed in brain.|
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1. DNA Res. 2000 Apr 28;7(2):143-50. 2. Nat Genet. 2004 Jan;36(1):40-5. 3. Science. 2005 Mar 11;307(5715):1621-5.
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