|Application ||WB, E|
|Description||This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.|
|Immunogen||Purified recombinant fragment of human PAX4 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Paired box protein Pax-4, PAX4|
WB~~1/500 - 1/2000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.|
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Provided below are standard protocols that you may find useful for product applications.
1. PLoS One. 2008 Mar 12;3(3):e1783. 2. Diabetes Res Clin Pract. 2008 Sep;81(3):365-9.
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