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ERK3 Antibody

Purified Mouse Monoclonal Antibody

  • E - ERK3 Antibody AO1545a

    Red: Control Antigen (100ng);
    Purple: Antigen (10ng);
    Green: Antigen (50ng);
    Blue: Antigen (100ng);

  • WB - ERK3 Antibody AO1545a
    Figure 1: Western blot analysis using ERK3 mAb against HEK293 (1) and ERK3(AA: 347-582)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - ERK3 Antibody AO1545a
    Figure 2: Flow cytometric analysis of Hela cells using ERK3 mouse mAb (green) and negative control (purple).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16659
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4E8
Isotype IgG1
Calculated MW 105kDa
Description The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. (provided by RefSeq) Tissue specificity: Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts
Immunogen Purified recombinant fragment of human ERK3 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 5597
Other Names Mitogen-activated protein kinase 6, MAP kinase 6, MAPK 6,, Extracellular signal-regulated kinase 3, ERK-3, MAP kinase isoform p97, p97-MAPK, MAPK6, ERK3, PRKM6
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsERK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAPK6
Synonyms ERK3, PRKM6
Function Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Tissue Location Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts
Research Areas
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1. J Cell Physiol. 2008 Dec;217(3):778-88. 2. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16710-5.

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$ 385.00
Cat# AO1545a
(40 western blots)
Availability: 7-10 days
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