|Application ||WB, ICC, E|
|Reactivity||Human, Mouse, Monkey|
|Description||The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.|
|Immunogen||Purified recombinant fragment of human ABCG2 expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||ATP-binding cassette sub-family G member 2, Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338, ABCG2, ABCP, BCRP, BCRP1, MXR|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
|Precautions||ABCG2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ABCP, BCRP, BCRP1, MXR|
|Function||High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in placenta. Low expression in small intestine, liver and colon.|
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Provided below are standard protocols that you may find useful for product applications.
1. Carcinogenesis. 2008 Dec;29(12):2289-97. 2. Pharm Res. 2009 Feb;26(2):449-58.
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