|Application ||WB, FC, E|
|Description||This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.|
|Immunogen||Purified recombinant fragment of human CRKL expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Crk-like protein, CRKL|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRKL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May mediate the transduction of intracellular signals.|
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1. Mol Cell Biol. 2009 Jun;29(11):3076-87. 2. Cell. 2009 Jul 23;138(2):389-403.
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