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CYP1A1 Antibody

Purified Mouse Monoclonal Antibody

  • E - CYP1A1 Antibody AO1662a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - CYP1A1 Antibody AO1662a
    Figure 1: Western blot analysis using CYP1A1 mAb against human CYP1A1 (AA: 203-461) recombinant protein. (Expected MW is 60 kDa)
  • IHC - CYP1A1 Antibody AO1662a
    Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using CYP1A1 mouse mAb with DAB staining.
  • IHC - CYP1A1 Antibody AO1662a
    Figure 3: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using CYP1A1 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04798
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6G5
Isotype IgG1
Calculated MW 58kDa
Description This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Immunogen Purified recombinant fragment of human CYP1A1 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 1543
Other Names Cytochrome P450 1A1,, CYPIA1, Cytochrome P450 form 6, Cytochrome P450-C, Cytochrome P450-P1, CYP1A1
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYP1A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP1A1
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Tissue Location Lung, lymphocytes and placenta.
Research Areas
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1. Cancer Res. 2009 Apr 1;69(7):2956-65. 2. Drug Metab Lett. 2009 Jan;3(1):18-27.

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$ 385.00
Cat# AO1662a
(40 western blots)
Availability: 7-10 days
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