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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   COTL1 Antibody   

COTL1 Antibody

Purified Mouse Monoclonal Antibody

  • WB - COTL1 Antibody AO1670a
    Figure 1: Western blot analysis using COTL1 mAb against human COTL1 (AA: 1-142) recombinant protein. (Expected MW is 16 kDa)
  • WB - COTL1 Antibody AO1670a
    Figure 2: Western blot analysis using COTL1 mAb against HEK293 (1) and COTL1 (AA: 1-142)-hIgGFc transfected HEK293 (2) cell lysate.
  • IHC - COTL1 Antibody AO1670a
    Figure 3: Immunohistochemical analysis of paraffin-embedded breast cancer tissues using COTL1 mouse mAb with DAB staining.
  • IHC - COTL1 Antibody AO1670a
    Figure 4: Immunohistochemical analysis of paraffin-embedded liver cancer tissues using COTL1 mouse mAb with DAB staining.
  • E - COTL1 Antibody AO1670a

    Figure 6: Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14019
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5C8
Isotype IgG1
Calculated MW 16kDa
Description This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.
Immunogen Purified recombinant fragment of human COTL1 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 23406
Other Names Coactosin-like protein, COTL1, CLP
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOTL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COTL1
Synonyms CLP
Function Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Cellular Location Cytoplasm, cytoskeleton. Nucleus membrane; Peripheral membrane protein
Tissue Location Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas
Research Areas
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1. Biochem J. 2009 Dec 14;425(1):265-74. 2. Exp Mol Med. 2009 May 31;41(5):354-61.

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$ 385.00
Cat# AO1670a
(40 western blots)
Availability: 7-10 days
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