|Application ||WB, IHC, FC, ICC, E|
|Description||The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA.It functions in close association with eIF4F and eIF4A. It binds near the 5'-terminal cap of mRNA in the presence of eIF4F and ATP. It promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both eIF4A and eIF4F|
|Immunogen||Purified recombinant fragment of human EIF4B expressed in E. Coli. |
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Eukaryotic translation initiation factor 4B, eIF-4B, EIF4B|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IF~~1/200 - 1/1000
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EIF4B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.|
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1. Mol Biol Cell. 2009 Jun;20(11):2673-83. 2. EMBO J. 2006 Jun 21;25(12):2781-91.
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