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VAV1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P15498 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2E11 |
| Isotype | IgG1 |
| Calculated MW | 98.3kDa |
| Description | The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. |
| Immunogen | Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 7409 |
|---|---|
| Other Names | Proto-oncogene vav, VAV1, VAV |
| Dilution | E~~1/10000 WB~~1/250 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VAV1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VAV1 |
|---|---|
| Synonyms | VAV |
| Function | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| Tissue Location | Widely expressed in hematopoietic cells but not in other cell types |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Acta Pharmacol Sin. 2011 Jan;32(1):99-107.2.Cell Tissue Res. 2011 Jul;345(1):163-75.
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$ 385.00
Cat# AO1740a
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