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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VAV1 Antibody   

VAV1 Antibody

Purified Mouse Monoclonal Antibody

  • E - VAV1 Antibody AO1740a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - VAV1 Antibody AO1740a
    Figure 1: Western blot analysis using VAV1 mAb against human VAV1 recombinant protein. (Expected MW is 49.3 kDa)
  • WB - VAV1 Antibody AO1740a
    Figure 2: Western blot analysis using VAV1 mAb against HEK293 (1) and VAV1 (AA: 121-324)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - VAV1 Antibody AO1740a
    Figure 3: Western blot analysis using VAV1 mouse mAb against Jurkat (1) cell lysate.
  • FC - VAV1 Antibody AO1740a
    Figure 4: Flow cytometric analysis of HeLa cells using VAV1 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15498
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2E11
Isotype IgG1
Calculated MW 98.3kDa
Description The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Immunogen Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 7409
Other Names Proto-oncogene vav, VAV1, VAV
Dilution E~~1/10000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVAV1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VAV1
Synonyms VAV
Function Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Tissue Location Widely expressed in hematopoietic cells but not in other cell types
Research Areas
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1.Acta Pharmacol Sin. 2011 Jan;32(1):99-107.2.Cell Tissue Res. 2011 Jul;345(1):163-75.

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$ 385.00
Cat# AO1740a
(40 western blots)
Availability: 7-10 days
Bulk Size
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