|Application ||WB, FC, E|
|Description||The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.|
|Immunogen||Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Proto-oncogene vav, VAV1, VAV|
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VAV1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.|
|Tissue Location||Widely expressed in hematopoietic cells but not in other cell types|
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Provided below are standard protocols that you may find useful for product applications.
1.Acta Pharmacol Sin. 2011 Jan;32(1):99-107.2.Cell Tissue Res. 2011 Jul;345(1):163-75.
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