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PAX5 Antibody

Purified Mouse Monoclonal Antibody

  • E - PAX5 Antibody AO1745a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - PAX5 Antibody AO1745a
    Figure 1: Western blot analysis using PAX5 mAb against human PAX5 recombinant protein. (Expected MW is 41.2 kDa)
  • IHC - PAX5 Antibody AO1745a
    Figure 2: Immunohistochemical analysis of paraffin-embedded brain tumors tissues using PAX5 mouse mAb with DAB staining.
  • IHC - PAX5 Antibody AO1745a
    Figure 3: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using PAX5 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02548
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7D3
Isotype IgG1
Calculated MW 45kDa
Description This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Immunogen Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 5079
Other Names Paired box protein Pax-5, B-cell-specific transcription factor, BSAP, PAX5
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPAX5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX5
Function May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
Cellular Location Nucleus.
Research Areas
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1.Cancer Res. 2011 Dec 15;71(24):7345-50.2.Am J Clin Pathol. 2010 Jan;133(1):41-8.

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$ 385.00
Cat# AO1745a
(40 western blots)
Availability: 7-10 days
Bulk Size
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