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SRY Antibody

Purified Mouse Monoclonal Antibody

  • E - SRY Antibody AO1747a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - SRY Antibody AO1747a
    Figure 1: Western blot analysis using SRY mAb against human SRY recombinant protein. (Expected MW is 49.4 kDa)
  • WB - SRY Antibody AO1747a
    Figure 2: Western blot analysis using SRY mouse mAb against NTERA-2 (1) cell lysate.
  • FC - SRY Antibody AO1747a
    Figure 3: Flow cytometric analysis of HepG2 cells using SRY mouse mAb (green) and negative control (red).
  • IHC - SRY Antibody AO1747a
    Figure 4: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using SRY mouse mAb with DAB staining.
  • IHC - SRY Antibody AO1747a
    Figure 5: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using SRY mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q05066
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1G4
Isotype IgG1
Calculated MW 23.9kDa
Description This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
Immunogen Purified recombinant fragment of human SRY (AA:1-204) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 6736
Other Names Sex-determining region Y protein, Testis-determining factor, SRY, TDF
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSRY Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SRY
Synonyms TDF
Function Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.
Cellular Location Nucleus speckle. Cytoplasm. Note=Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity).
Research Areas
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1.J Biol Chem. 2009 Dec 18;284(51):35670-80.2.FASEB J. 2009 Nov;23(11):4029-38.

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$ 385.00
Cat# AO1747a
(40 western blots)
Availability: 7-10 days
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