|Application ||WB, IHC, E|
|Description||This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.|
|Immunogen||Purified recombinant fragment of human AlCAM (AA: 405-524) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||CD166 antigen, Activated leukocyte cell adhesion molecule, CD166, ALCAM, MEMD|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AlCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
1.Vascul Pharmacol. 2011 Mar-Jun;54(3-6):93-9.2.Int J Gynecol Cancer. 2011 Apr;21(3):523-8.
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